AstraZeneca's sipavibart has shown a statistically significant reduction in the incidence of symptomatic COVID-19 compared to control treatments, which included tixagevimab/cilgavimab or a placebo, in immunocompromised patients, according to the results of the SUPERNOVA Phase III pre-exposure prophylaxis (prevention) trial.
The trial successfully met its dual primary endpoints: a reduction in the relative risk of symptomatic COVID-19 caused by any SARS-CoV-2 variant, and a reduction in the relative risk of infections caused by variants not containing the F456L mutation.
SUPERNOVA has indicated the potential benefits of sipavibart amidst a landscape of evolving variants, with COVID-19 cases during the trial being attributed to several different SARS-CoV-2 variants.
Sipavibart, previously known as AZD3152, is an investigational long-acting monoclonal antibody designed to provide comprehensive and potent protection across Omicron and ancestral viral variants by neutralizing the interaction of the spike protein with the host receptor ACE2.
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