FX.co ★ Shattuck Announces Additional Positive Data From Phase 1B Study Of SL-172154 With Azacitidine

Shattuck Labs, Inc. (STTK) has reported additional positive interim results from its Phase 1B study involving SL-172154 in combination with Azacitidine (AZA) for frontline treatment of higher-risk myelodysplastic syndromes (HR-MDS) and acute myeloid leukemia (AML) patients.

The study showed an objective response rate (ORR) of 67% in HR-MDS patients, predominantly those with TP53 mutations, treated with the SL-172154 and AZA combination. Out of these, 42% of patients reached a complete remission (CR), with the median time to CR being 3.6 months.

For frontline TP53m AML patients, the ORR was 43%, with 29% achieving CR.

Additionally, SL-172154 exhibited a manageable interim safety profile when used in combination with AZA.

"Enrollment is now underway for our randomized, controlled expansion cohort in frontline HR-MDS patients, and we expect to engage in regulatory discussions later this year regarding the registrational strategy for SL-172154," stated Lini Pandite, Chief Medical Officer of Shattuck.