FX.co ★ Johnson & Johnson Says Darzalex Regimens Show Meaningful Responses In Patients With Multiple Myeloma

Johnson & Johnson (JNJ) announced on Friday the results from three studies highlighting the clinical efficacy of Darzalex (daratumumab) and Darzalex Faspro (daratumumab and hyaluronidase-fihj) in maintenance therapy regimens.

The Phase 3 AURIGA study revealed that Darzalex Faspro plus lenalidomide maintenance therapy following autologous stem cell transplant (ASCT) significantly increased MRD-negative conversion rates at 12 months compared to lenalidomide maintenance alone in patients with newly diagnosed multiple myeloma (NDMM).

Furthermore, Darzalex Faspro plus lenalidomide maintenance therapy demonstrated a potential benefit in progression-free survival (PFS) with no new safety concerns reported.

"The significant improvement in MRD-negative conversion rates and the promising progression-free survival data suggest that this maintenance regimen has the potential to improve longer-term outcomes for patients with newly diagnosed multiple myeloma who are transplant-eligible," stated Dr. Ashraf Badros, Professor of Medicine at the University of Maryland School of Medicine and Director of the Multiple Myeloma Service at the University of Maryland Greenebaum Comprehensive Cancer Center. "Combining Darzalex Faspro with lenalidomide in the maintenance setting offers an advantage over lenalidomide alone for patients who are newly diagnosed with multiple myeloma and are anti-CD38 naive."